Therapeutic Potential of Cell Penetrating Peptides (CPPs) and Cationic Polymers for Chronic Hepatitis B

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Therapeutic Potential of Cell Penetrating Peptides (CPPs) and Cationic Polymers for Chronic Hepatitis B

Chronic hepatitis B virus (HBV) infection remains a major health problem worldwide. Because current anti-HBV treatments are only virostatic, there is an urgent need for development of alternative antiviral approaches. In this context, cell-penetrating peptides (CPPs) and cationic polymers, such as chitosan (CS), appear of particular interest as nonviral vectors due to their capacity to facilita...

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cell-penetrating peptides (cpps): a tool in modern biotechnology

the major limitation in the application of bioactive molecule is their low permeation across plasma membrane. in 1988 it was discovered, that a natural polycationic protein, the trans-acting activator of transcription (tat) of the human immunodeficiency virus (hiv-1), passed very efficiently through cell membrane of cultured mammalian cells. tat became known as the first cell penetrating peptid...

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Cell-penetrating peptides and their therapeutic applications

The process of introducing drugs into cells has always proved a major challenge for research scientists and for the pharmaceutical industry. The cell membrane is selectively permeable and supports no generic mechanism for their uptake. A drug must be either highly lipophilic or very small to stand a chance of cellular internalization. These restrictions mean that the repertoire of possible drug...

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ژورنال

عنوان ژورنال: International Journal of Molecular Sciences

سال: 2015

ISSN: 1422-0067

DOI: 10.3390/ijms161226094